Perivascular nerve fibres are increased in the epicardium while perivascular adipose tissue is decreased in the myocardium in patients with acute myocardial infarction

Abstract Background Vasospasm is an important etiological factor in the induction of acute myocardial infarction (AMI). PeriVascular Nerve Fibres (PVNF) and Adipose Tissue (PVAT) play role vasoregulation, although detailed information their heart missing AMI patients. In present study we have analysed PVNF PVAT deceased Methods Sections epicardial coronary arteries were obtained at autopsy from patients (N=16) controls without disease (N=7). Infarct age was between 3 6 hours old. Stenosis quantified a HE stained slide. To analyse intramyocardial vasculature samples taken left ventricle (in infarcted area). fibres using specific S100 antibody. Putative activation these nerves antibody against neuropeptide Y (NPY). S100+ NPY+ nerve by light microscopy then calculated per square mm adventitia surface areas. Elastica Von Gieson (EvG) staining. Results did not correlate with PVNF. had significant increase epicardium but myocardium. NPY non-significantly increased myocardium compared controls. significantly decreased Conclusion The decrease suggest that they might induction, independent atherosclerotic changed arteries. Funding Acknowledgement Type funding sources: None.